Week 10 NFL odds, lines, totals, spreads for every game, including Giants-Commanders, 49ers-Cowboys

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. NFL Week 10 spreads and totals for every game, including Commanders-Giants, 49ers-Cowboys and Steelers-Bengals Nov 12, 2026 at 9:24 am ET • 2 min read The Week 10 NFL schedule features 14 games, starting on Thursday Night Football when the New York Giants host the Washington Commanders. According to the latest NFL odds, the Giants are favored by 2.5 points, while the over/under for total points scored is 41. The Rams are the largest favorite at 9.5 points against the Cardinals, according to the Week 10 NFL spreads. Dolphins vs. Colts on Sunday carries the lowest total at 38.5 points. Dolphins quarterback Malik Willis (groin) is inactive against Indianapolis after being placed on injured reserve. Bet on every NFL game with the latest DraftKings promo code, where new users get $200 in bonus bets plus 3 free months of NBA League Pass after making a $5 wager: Below you'll find the NFL betting odds for every Week 10 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 10 here. Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get a $55 bonus:** Odds provided by DraftKings are subject to change **Thursday, November 12Washington Commanders vs. New York GiantsSpread: Giants -2.5Moneyline: Giants (-135), Commanders (+110)Total: 41Sunday, November 15New England Patriots vs. Detroit LionsSpread: Lions -3Moneyline: Lions (-148), Patriots (+124)Total: 51.5Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get a $55 bonus:Kansas City Chiefs vs. Atlanta FalconsSpread: Chiefs -3.5Moneyline: Chiefs (-175), Falcons (+145)Total: 45.5Bet on NFL games with the latest DraftKings promo code and get $200 in bonus bets and 3 free months of NBA League Pass after making a $5 wager: Houston Texans vs. Cleveland BrownsSpread: Texans -4.5Moneyline: Texans (-192), Browns (+160)Total: 39.5Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get a $55 bonus:Minnesota Vikings vs. Green Bay PackersSpread: Packers -3.5Moneyline: Packers (-180), Vikings (+150)Total: 42.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Jacksonville Jaguars vs. Tennessee TitansSpread: Jaguars -9.5Moneyline: Jaguars (-485), Titans (+370)Total: 47.5Claim the Fanatics Sportsbook promo code CBSFAN350 here to get $350 in FanCash:Miami Dolphins vs. Indianapolis ColtsSpread: Colts -3.5Moneyline: Colts (-192), Dolphins (+170)Total: 38.5Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:Carolina Panthers vs. New Orleans SaintsSpread: Saints -1.5Moneyline: Saints (-108), Panthers (-112)Total: 47.5Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get a $55 bonus:Buffalo Bills vs. New York JetsSpread: Bills -7.5Moneyline: Bills (-470), Jets (+360)Total: 51.5Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Seattle Seahawks vs. Las Vegas RaidersSpread: Seahawks -3.5Moneyline: Seahawks (-170), Raiders (+142)Total: 43.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Los Angeles Rams vs. Arizona CardinalsSpread: Rams -9.5Moneyline: Rams (-429), Cardinals (+360)Total: 39.5Claim the Fanatics Sportsbook promo code CBSFAN350 here to get $350 in FanCash:San Francisco 49ers vs. Dallas CowboysSpread: 49ers -3.5Moneyline: 49ers (-218), Cowboys (+180)Total: 55.5Claim the Fanatics Sportsbook promo code CBSFAN350 here to get $350 in FanCash:Pittsburgh Steelers vs. Cincinnati BengalsSpread: Bengals -3.5Moneyline: Bengals (-180), Steelers (+150)Total: 47.5Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get a $55 bonus:Monday, November 16Los Angeles Chargers vs. Baltimore RavensSpread: Ravens -4.5Moneyline: Ravens (-205), Chargers (+170)Total: 38.5Bet on NFL games with the latest DraftKings promo code and get $200 in bonus bets and 3 free months of NBA League Pass after making a $5 wager: Week 10 byes: Bears, Broncos, Eagles and Buccaneers.