This page may contain affiliate links. If you click and sign up, make a deposit, or place a wager, we may earn a commission at no additional cost to you. Jamey Eisenberg tabs Jared Goff as his Start of the Week, while last year's MVP should get off to a hot start against the 49ers Sep 9, 2026 at 5:42 pm ET • 2 min read Welcome back. We've missed you. For some of you, it's been a while. You haven't thought about setting a Fantasy roster for months. Most of you, however, have been here for weeks. Waiting. Salivating. Excited to set your first lineup. And now it's here -- Week 1. So let's get started. The draft was the first step, and your team is ready to go. The players you drafted are ready to deliver on the expectations you've set for them, which is a championship or bust. Sure, you want to have fun along the way, but the ultimate goal is the title at the end of the season. That's the way it should be, right? You want to feel positive about the roster you built. You want to expect the best and hope no one gets injured, everyone reaches their ceiling and all of those sleepers you drafted in the late rounds become stars. Now, we know that's not realistic. It's how you manage your team during the season that will determine your fate. As much as the draft sets the table for the start of the year, the waiver wire is the most important part of the process. You need to be prepared. You also need to make the right start and sit decisions -- and that's why you're here. Our job is to make it easy for you. We've done the research and allowed the matchups to determine if a player should have a positive or negative outcome each week. We're not always going to be right -- far from it. But if you keep coming back here all season, your Fantasy team will benefit. You'll give yourself the best chance to win -- and hold that trophy to celebrate a championship. Week 1 is here. Let's have some fun. Pick NFL at Underdog Fantasy, where new users who play $5 now get $100 in site credits with promo code CBSSPORTS2 in select states. Projections powered by Sportsline START 'EM & SIT 'EM Quarterbacks Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline START 'EM & SIT 'EM Running Backs Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Jaguars (vs. CLE)It's an unofficial count, but Deshaun Watson threw nine interceptions in the first 12 days of training camp practice. This will be Watson's first game since Week 7 in 2024, when he ruptured his Achilles, and the Jaguars' defense should be ready. Jacksonville has allowed just four touchdowns and 10 interceptions in the past eight games in the regular season, going back to Week 11 last year. Projections powered by Sportsline Ravens (at IND)Cowboys (at NYG)Bills (at HOU) Projections powered by Sportsline Chiefs (vs. DEN) The Chiefs DST will eventually turn into a starting Fantasy option, and you'll want to use this unit in Week 3 at Miami and Week 4 at Las Vegas. But in Week 1 against Denver, I would sit the Chiefs DST. There are a lot of new additions for coordinator Steve Spagnuolo, and it could take time for this defense to gel. The Broncos also have a standout offensive line, and Bo Nix (ankle) is healthy for Week 1. Jaylen Waddle also brings an added element to Denver's offense, and I don't expect the Chiefs DST to be overly productive in this matchup. Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline
Fantasy Football Week 1 Start 'Em & Sit 'Em: Jared Goff is the Start of the Week in favorable spot vs. Saints
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