College Football Week 6 Bets: Three Picks for Saturday’s Biggest Games

Oct 3, 2026; Starkville, Mississippi, USA; Alabama Crimson Tide head coach Kalen DeBoer reacts toward a referee during the fourth quarter against the Mississippi State Bulldogs at Davis Wade Stadium at Scott Field. Mandatory Credit: Petre Thomas-Imagn Images Week six of the college football season is a sneaky very solid slate of games.There’s only two ranked matchups this week but a ton of ranked teams who will be on upset alert all Saturday long.Here’s my picks for my three favorite games of the day.#7 Indiana (-7.5) vs Nebraska Total: 47.5Indiana looked rough against Northwestern, the only opponent they’ve played thus far with a pulse. However, despite the Wildcats keeping that game close in the box score, I’m not really sure that game was actually all that close. On the other hand, Nebraska is undefeated and unranked for a good reason. They’re just not that good.That being said, Anthony Colandrea is a guy who could cause an iffy Hoosier pass defense some problems. I still think this is the game where Curt Cignetti gets his guys going with Ohio State on the schedule next week. Josh Hoover continues his phenomenal start to this year, and Indiana rolls into Lincoln and wins by 2-3 scores.Pick: Indiana -7.5 Our Current Best OffersChannel debug: betting #21 UCLA vs #13 Oregon (-11.5) Total: 59.5There’s no better measuring stick game than this one. UCLA’s offense has looked tremendous through the first four games of the Bob Chesney era, while Oregon’s been shaky through their difficult schedule, they could really get back into the drivers seat with a big win over their former PAC-12 foes. With Dante Moore out for the foreseeable future, I don’t actually think Oregon’s offense will slow down all that much. Former Cornhusker, Dylan Raiola looked great in relief of Moore last week, and I expect another solid performance out of him this week. That being said, Oregon’s defense is still miles behind their offense, and Wayne Knight might run all over them, just like he did with JMU in last year’s playoffs. I’m not sure Chesney gets his revenge just yet, but I think this game stays very close.Pick: UCLA +11.5 and o59.5#2 Georgia vs #6 Alabama (-1.5) Total: 51.5The game of the week, and maybe season will land one of these two teams in the drivers seat for the SEC. Both teams avoid Texas in the regular season, and whomever comes out on top of this one will likely find themselves in the SEC Championship. I’m incredibly high on Keelon Russell and Bama is looking like a national title contender for the first time under Kalen DeBoer. Georgia’s looked great so far, but they haven’t played anyone so we just don’t know what to expect out of them. Georgia offensive coordinator, Mike Bobo always seems to struggle in big games, and against an opportunistic defense like Alabama, I think he’s going to call the game far too conservatively. I like Bama in a close one.Pick: Alabama -1.5 Our Current Best OffersChannel debug: betting